Venous Thromboembolism Outcomes by Geographic Region and Self-Reported Race: Insights from the RIETE Registry

Alfonso J Tafur; Benjamin Brenner; Pablo Demelo-Rodríguez; Leticia Guirado; José María Pedrajas; Lucia Mazzolai; Ana Cristina Montenegro; Raimundo Tirado; Aurora Villalobos; Manuel Monreal; RIETE Investigators

doi:10.1055/a-2615-4591

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost
DOI: 10.1055/a-2615-4591

Stroke, Systemic or Venous Thromboembolism

Venous Thromboembolism Outcomes by Geographic Region and Self-Reported Race: Insights from the RIETE Registry

Alfonso J Tafur

¹Department of Vascular Medicine, Endeavor Health, Evanston, Illinois, United States

²Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States

,

Benjamin Brenner

³Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel

,

Pablo Demelo-Rodríguez

⁴Department of Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain

,

Leticia Guirado

⁵Department of Internal Medicine, Hospital Universitario Virgen de Arrixaca, Murcia, Spain

,

José María Pedrajas

⁶Department of Internal Medicine, Hospital Clínico San Carlos, Madrid, Spain

,

Lucia Mazzolai

⁷Department of Angiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland

,

Ana Cristina Montenegro

⁸Department of Vascular Medicine, Hospital Universitario Fundacion Santa Fe de Bogotá, Bogotá, Colombia

,

Raimundo Tirado

⁹Department of Internal Medicine, Hospital Infanta Margarita, Córdoba, Spain

,

Aurora Villalobos

¹⁰Department of Internal Medicine, Hospital Regional Universitario de Málaga, Málaga, Spain

,

Manuel Monreal

¹¹Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Badalona, Spain

,

RIETE Investigators

› Author Affiliations

Abstract

Background

Venous thromboembolism (VTE) outcomes are influenced by various factors, including race and geographic location. This study aimed to evaluate the associations between race, geographic location, and VTE-related outcomes using real-world data.

Methods

We analyzed data from 42,206 patients with acute VTE enrolled in the RIETE registry between June 2016 and June 2024. Patients were categorized by self-reported race/ethnicity: White (40,258), Arab (995), Asian (689), and Black (264). Baseline characteristics, comorbidities, treatment strategies, and outcomes (including recurrences, major bleeding, and mortality) were compared across groups and regions. Multivariable analyses were performed to adjust for confounders, including geographic location and comorbidities.

Results

Arabic and Asian patients were generally younger, had fewer comorbidities, and were more likely to receive direct oral anticoagulants than White patients. In unadjusted analysis, non-White patients had higher rates of deep vein thrombosis (DVT) recurrence and mortality. After multivariable adjustment, most differences disappeared. Notably, White patients enrolled in Asian centers had higher DVT recurrence (4.54 vs. 1.10/100 patient-years, respectively) and mortality rates (27.9 vs. 8.88/100 patient-years, respectively) than those in European centers, and Arab patients in Asia had higher mortality compared to those in Europe (24.1 vs. 8.26/100 patient-years, respectively).

Conclusion

Geographic location, likely representing healthcare infrastructure, had a greater influence on VTE outcomes than self-reported race alone.

Keywords

race - VTE - geography

Full Text

References

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Supplementary Material

Supplementary Material